| Biomembrane Lab Funding History |
|
| Sponsor |
Project Title |
Dates |
PI |
Goal |
|
|
Active Funding
|
 |
NIH-R01 (NIGMS, 1R01GM081705-01)
|
|
"Chip-based and Single Transporter Assays of Multidrug Resistance Transporters" |
08/2007 - 07/2012 |
| PI: M. Mayer |
| Co-Pi: Dr. Suresh Ambudkar (NCI) |
|
To develop functional assays that will make it possible
to characterize better, and target effectively, MDR-associated transporters from cancer cells. |
 |
Thermo Fisher – CCG Collaborative Pilot Project Initiative
|
|
“Electrophysiology on Arrays of Human Biomembranes” |
02/2008 - 01/2009 |
|
Carry out electrophysiology on an array of human
biomembranes.
|
 |
Wallace H. Coulter Foundation
|
|
“Functional Screening of Small Molecules for Inhibiting the Ion Channel Activity of beta-Amyloid Peptides” |
04/2006 - 05/2008 |
| PI: M. Mayer |
| Co-Pi's: Dr. Scott Turner (UMHS) and Dr. Jerry Yang (UCSD) |
|
Electrophysiological screening for molecules that inhibit A-beta ion channel formation. |
 |
MTTC05-101 Michigan Technology Tri-Corridor Fund
|
|
“Diagnosis and Therapeutic Monitoring of Multiple Sclerosis by Screening for Ion Channel Activity” |
09/2005 - 08/2008 |
| PI: M. Mayer |
| Co-Pi: Dr. Daniel Mikol (UMHS), Dr. David Fox (UMHS), and
Kirk Schroeder (Essen Instruments) |
|
Develop an assay for early diagnosis of Multiple Sclerosis and explore the potential of this assay for therapeutic monitoring. |
 |
NSF 02-111 CAREER Award
|
|
“Bio-Inspired Transport Assays and Single-Molecule Detection using Micro- and Nanopores” |
08/2005 - 07/2010 |
|
Develop microfabricated setups to develop novel assays for membrane transport proteins. |
|
|
Previous Funding
|
|
Thermo Fisher – CCG Collaborative Pilot Project Initiative
|
|
“Efficient and Parallel Formation of Membrane Protein Arrays by Hydrogel- based Microcontact printing” |
02/2006 - 01/2008 |
|
Develop an efficient and economic procedure to fabricate functional membrane protein arrays. |
 |
Serono Inc.
|
|
“Kv1.3 expression and function in T-cells of multiple sclerosis patients-correlation with clinical activity” |
07/2006 - 06/2007 |
| PI: D. Mikol |
| Co-Pi: M. Mayer |
|
Measure Kv1.3 channel expression and function on T-cell subsets, using FACS analysis and IonWorks HT technology. |
|
NIH: Cellular Biotechnology Training Program
|
|
“Bio-Inspired transport Assays and Single-Molecule Detection using Micro- and Nanopores” |
07/2004 - 06/2007 |
|
Interdisciplinary training of a Ph.D. student in cellular biotechnology. |
 |
AISIN/IMRA America Inc.
|
|
“Immuno-gated Nanopores: Ultrasensitive Diagnostic Assays based on Binding of Single Antibodies” |
07/2004 - 06/2007 |
| PI: M. Mayer |
| Co-Pi: Dr. Alan Hunt |
|
Develop ultrasensitive and portable immunoassays based on nanofabricated pores. |
 |
U of M College of Engineering, Special Faculty Equipment Initiative FY 05
|
|
“Total Internal Reflectance Fluorescence (TIRF) Microscopy Setup” |
2005 |
| PI: M. Mayer |
| Co-Pi: Ten Co-PI's from the College of Engineering |
|
Purchase and install a state-of-the-art microscope for single-molecule detection, nanoscience, and nanoengineering. |
|
