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Francesc Marti

Francesc Marti

Research Investigator

Education/Training

  • B.Sc. Biology, Autonomous University of Barcelona, Spain, 1986
  • M.S. Biochemistry & Molecular Biology, Autonomous University of Barcelona, Spain, 1990
  • Ph.D. Biochemistry & Molecular Biology, Autonomous University of Barcelona, Spain, 1995
  • Post-doctoral Fellowship in Signal Transduction, Memorial Sloan Kettering Cancer Center, NY, 1996-1998
  • Post-doctoral Fellowship in Signal Transduction, Hospital for Special Surgery-Cornell University, NY, 1998-2002

Positions and Employment

  • 1996-1998 Postdoctoral Fellow. Laboratory of Human Immunogenetics, Laboratory head: Dr. Bo Dupont. Sloan-Kettering Institute for Cancer Research, Memorial Sloan-Kettering Cancer Center, NY.
  • 1998-2002 Postdoctoral Fellow, Laboratory of Cell Signaling, Laboratory head: Dr. Philip King. Hospital for Special Surgery, Weill Medical College of Cornell University, NY.
  • 2002-pres. Research Investigator, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI.
  • 2006-pres. Research Investigator, Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI.

Publications: Original Research

1. Martí,F.; Piñol,G.; Rueda,F.
"A method to obtain mononuclear cells significantly free of platelets."
Biol & Clin Hematol, 10:149-153, 1988.
2. Piñol,G.; Martí,F.; Rueda,F.
"Monoclonal antibodies obtained against human Anti-thrombin III."
Biol & Clin Hematol, 10:153-159, 1988.
3. Rueda,F.; Martí,F.; Piñol, G.; Remacha,A.
"Artefactual low lymphocyte activity by platelet contamination in the mononuclear cells preparations."
American Journal of Hematology, 31:126-127, 1989.
4. Rueda,F.; Piñol,G.; González-Garrigues,M.; Martí,F.; Fabra,A.
"Transforming Growth Factor release by human tumor cell lines and their interactions with other growth factors."
Anticancer Research, 9(4):1245-1248, 1989.
5. Rueda,F.; Remacha,A.; Martí,F.; Piñol,G.; Soler,J.; Guañabens,C.; Gimferrer,E.
"Different lymphocyte activity in patients with Polycythemia Vera versus Secondary Polycythemia and healthy blood donors."
Acta Haematologica, 83(1) : 31-34, 1990.
6. Piñol,G.; Martí,F.; Rueda,F.; Puig,Ll.
"Effect of minoxidil on the DNA synthesis in fibroblasts cultures from normal and keloid skin."
Med. Cutan. Ibero Lat. Am., 18(1):13-17, 1990.
7. Rueda,F.; Piñol, G.; Martí,F.; Pujol-Moix,N.
"Growth factor expression in mononuclear cells from myeloproliferative disorders."
Biol & Clin Hematol, 12 (2): 47-51, 1990.
8. Rueda,F.; Piñol,G.; Martí,F.; Pujol-Moix,N.
"Abnormal levels of Platelet-specific proteins and mitogenic activity in myeloproliferative disease."
Acta Haematologica, 85(1):12-15, 1991.
9. Martí,F.; Miralles,A.; Peiró,M.; Amill,B.; Dalmases,C.; Piñol,G.; Rueda,F.; García,J.
"Differential effect of cryopreservation on Natural Killer cell and Lymphokine Activated Killer cell Activities."
Transfusion, 33(8): 651-655, 1993.
10. Martí,F.; Muñoz,J.; Peiró,M.; Bertran,E.; Ferran,C.; Octavio,C.; García,J.; Rueda,F.
"Higher cytotoxic activity and increased levels of IL-1 , IL-6 and TNF- in patients undergoing cardiopulmonary bypass."
American Journal of Hematology, 49(3):237-239, 1995.
11. Pardo,N.; Martí,F.; Peiró,M.; Bertran,E.; Fraga,G.; Amill,B.; Illa,J.; Rueda,F.; Cubells, J.
"Immunotherapy with high dose of Interleukin-2 after autologous bone marrow transplantation in childhood Neuroblastoma patients. I. Following of tolerance and clinical response. "
Anales de Pediatría Española, 43(1):23-29, 1995.
12. Martí,F.; Pardo,N.; Peiró,M.; Bertran,E.; Fraga,G.; Amill,B.; Illa,J.; Cubells,J.; Rueda,F.
"Immunoterapy with high doses of Interleukin-2 after autologous bone marrow transplantation in childhood Neuroblastoma patients. II. Following of Natural Killer cytotoxicity parameters."
Anales de Pediatría Española, 43(2):105-111, 1995.
13. Martí,F.; Pardo,N.; Peiró,.M; Bertran,E.; Amill.B.; García,J.; Cubells,J.; Rueda,F.
"Progression of natural immunity during the course of one year-treatment of residual disease in Neuroblastoma patients with high doses of Interleukin-2 after Autologous Bone Marrow Transplantation."
Experimental Hematology, 23(14):1445-1452, 1995.
14. Rueda,F.; Martí,F.; Pardo,N.; Badell,I.; Peiró,M.; Bertran,E.; Villén,E.; García,J.; Cubells,J.
"Interleukin-2 in Neuroblastoma: clinical perspectives based on biological studies."
Cancer Biotherapy & Radiopharmaceuticals, 11(5): 303-308, 1996.
15. Pardo,N.; Martí,F.; Fraga,G.; Illa,J.; Badell,I.; Peiró,M.; Bertran,E.; García,J.; Rueda,F.; Cubells,J.
"High-dose systemic Interleukin-2 therapy in stage IV Neuroblastoma for one year after Autologous Bone Marrow Transplantation: pilot study."
Medical and Pediatric Oncology, 27(6): 534-539, 1996.
16. Ferra,C.; de Sanjosé,S.; Lastra,CF.; Martí,F.; Marino,E.L.; Sureda,A.; Brunet,S.; Gallardo,D.; Berlanga,JJ.; García,J.; Grañena,A.
"Pentoxifylline, ciprofloxacin and prednisone failed to prevent transplant-related toxicities in bone marrow transplant recipients and were associated with an increased incidence of infectious complications."
Bone Marrow Transplantation, 20(12): 1075-1080, 1997.
17. Martí,F.; Xu,C.W.; Selvakumar,A.; Brent,R.; Dupont,B.; King,P.D.
"LCK-phosphorylated human Killer cell Inhibitory Receptors recruit and activate Phosphatidylinositol 3-kinase."
Proceedings of the National Academy of Sciences USA, 95(20): 11810-11815, 1998.
18. Sundvold,V.; Torgersen,K.M.; Post,N.H.; Martí,F.; King,P.D.; Rottingen,J.A.; Spurkland,A,; Lea,T.
"T cell-specific adapter protein inhibits T cell activation by modulating Lck activity."
Journal of Immunology, 165(6): 2927-2931, 2000.
19. Martí,F.; Krause, A.; Dupont,B.; Sadelain,M.; King,P.D.
"Negative-feedback regulation of CD28 costimulation by a novel MAP-kinase phosphatase, MKP6."
Journal of Immunology, 166(1): 197-206, 2001.
20. Martí,F.; Post,N.H.; Chan,E.; King,P.D.
"A transcription function for the T-cell specific Adapter (TSAd) Protein in T cells: critical role of the TSAD SH2 domain."
Journal of Experimental Medicine, 193(12): 1425-1430, 2001.
21. Martí,F.; Bertran,E.; Llucià,M.; Villén,E.; Peiró,M.; García,J.; Rueda,F.
"Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8."
Journal of Leukocyte Biology, 72(3): 590-597, 2002.
22. Brentjens,R.J.; Latouche,J.B.; Santos,E.; Marti,F.; Gong,M.C.; Lyddane,C.; King,P.D.; Larson, S.; Weiss,M.; Rivière,I.; Sadelain,M.
"Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15."
Nature Medicine, 9(3):279-286, 2003.
23. Drappa,J.; Kamen,L.A.; Chan,E.; Georgiev,M.; Ashany,D.; Martí,F.; King,P.D.
"Impaired T cell death and Lupus-like autoimmunity in T-cell specific Adapter Protein-deficient mice."
Journal of Experimental Medicine, 198(5): 809-821, 2003.
24. Martí,F.; King,P.D.
"The p95-100 kDa ligand of the T-cell specific Adapter (TSAd) protein Src-homology-2 (SH2) domain implicated in TSAd nuclear import is p97 Valosin-containing protein (VCP)."
Immunology Letters, 97(2): 235-245, 2005.
25. Blank,M.C.; Masuda,E.; Martí,F.; King,P.D.; Redecha,P.B.; Wurzburger,R.J.; Peterson, M.G.E.; Tanaka,S.; Pricop,L.
"Altered transcription of the human Fc?RIIB gene mediated by a promoter polymorphism and association with systemic lupus erythematosus."
Human Genetics 117(2-3):220-7, 2005.
26. Martí,F.; Garcia,G.G.; MacGregor,J.N.; Lapinski,P.E.; King,P.D.
"Essential role of the T-cell specific Adapter protein in the activation of LCK in peripheral T cells."
Journal of Experimental Medicine, 203(2):281-7, 2006.

Publications: Reviews

1. Martí,F.; Rueda,F.; Puig,L.
"The soluble Interleukin-2 receptor in dermatology."
Med. Cutan. Ibero Lat. Am.,19: 62-68, 1991.
2. Martí,F.; Peiró,M.; Rueda,F.
"Immunotherapeutical treatment with TIL in dermatology."
Piel, 8(2): 105-109, 1993.
3. Martí,F.; Lapinski,P.E.; King,P.D.
SHD2A (ID A002075).
AfCS-Nature Molecule Pages, doi: 10.1038/mp.a002075.01, 2004.
4. Martí,F.; Lapinski,P.E.; King,P.D.
"The emerging role of the T-cell specific Adapter (TSAd) protein as an autoimmune disease-regulator in mouse and man."
Immunology Letters, 97(2): 165-171, 2005.
5. Martí,F.; King,P.D.
MKP6/Dusp14 D2A (ID A001547).
AfCS-Nature Molecule Pages, doi:10.1038/mp.a001547.01, 2006.
6. Lapinski,P.E.; MacGregor,J.N.; Martí,F.; Lapinski,P.E.; King,P.D.
"The T cell-specific adapter protein functions as a regulator of peripheral but not central immunological tolerance."
Adv. Exp. Med. Biol. 584:73-87, 2006.

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