Lab Logo PUBLICATIONS Biomembrane Lab
 
| home | research | publications | people | awards | funding | funstuff | calendar |
Papers Conferences Patents
Papers from the Biomembrane Lab, University of Michigan 2008 | 2007 | 2006 | 2005
2008
41. "Generating arrays with high content and minimal consumption of functional membrane proteins"
Majd S., Mayer M.*
Submitted, 2008.		  
40. "A semi-synthetic ion channel platform for detection of enzyme activity"
Blake S., Jiang X., Capone R., Estes D.J., Mayer M.*, Yang J.*
Submitted, 2008.		  
39. "Alzheimer's Disease-Related Amyloid-Beta Ion Channels: Resolving a Controversy"
Capone R., Prangkio P., Sauer A.M., Bautista M.R., Turner R.S., Yang J., Mayer M.*,
Submitted, 2008.		  
38. "Chemically reactive derivatives of gramicidin A for developing ion channel-based nanoprobes"
Blake S., Capone R., Mayer M.*, Yang J.*
Bioconjugate Chem., 2008, in press.
37. "Ultrafast laser fabrication of submicrometer pores in glass"
An R., Uram J.D., Yusko E.C., Ke K., Mayer M., Hunt A.J.*
Optics Letters, 2008, 33, 1153-1155. Abstract , Full Text (pdf)
  This paper demonstrate rapid fabrication of submicrometer-diameter pores in borosilicate glass using femtosecond laser machining and subsequent wet-etch techniques. The technique presented in this work affords repeatable and direct fabrication of high-quality pores with diameters between 400-800 um, with smaller pores possible with a subsequent deposition of SiO2 by PECVD.
36. "Detection and quantification of lipid membrane binding on silca micro-tube resonator sensor"
Ling T., Majd S., Mayer M., Guo L. J.*
Proc. SPIE, 2008, 6862, 68620B1-68620B8. Abstract , Full Text
  This paper studies the binding of a lipid membrane onto a micro-tube sensor that is probed by a prism coupling technique. The presented method affords a sensitive technique to detect binding of proteins to a lipid bilayer.
35. "Films of agarose enable rapid formation of giant liposomes in solutions of physiological ionic strength"
Horger K.S., Estes D.J., Capone R., Mayer M.*
Submitted, 2008.		  
34. "High-throughput profiling of ion channel activity in primary human lymphocytes"
Estes D.J., Memarsadeghi S. (D.J.E. and S.M. contributed equally), Lundy S.K., Mikol D.D., Fox D.A., Mayer M.*
Anal. Chem., 2008, 80, 3728-3735. Abstract , Full Text (pdf)
  This paper presents a high-throughput method to quantify the functional activity of potassium (K+) ion channels in primary human lymphocytes. This work affords insight into using Kv1.3 activity as a marker of T cell activation, and also provides a general methodology for high-throughput profiling of voltage-gated ion channel activity in a range of primary cell types.
  This article was highlighted as a Research Profile in the June 1, 2008 issue of Analytical Chemistry
33. "Characterization of changes in the viscosity of lipid membranes with the molecular rotor FCVJ"
Nipper M.E., Majd S., Mayer M., Lee J., Theodorakis E. A., Haidekker M. A.*
Biochim. Biophys. Acta, 2008, 1778, 1148-1153. Abstract , Full Text
  The purpose of this study is to examine the fluorescent behavior of FCVJ in model membranes exposed to various agents of known influence on membrane viscosity, such as alcohols, dimethyl sulfoxide (DMSO), cyclohexane, cholesterol, and nimesulide.
32. "Noise and bandwidth of current recordings from submicrometer pores and nanopores"
Uram J. D., Ke K., Mayer M.*
ACS Nano, 2008, 2, 857-872. Abstract , Full Text (pdf)
  In this report, we present a detailed theoretical and experimental study on the noise and signal bandwidth of current recordings from glass and polyethylene terephthalate (PET) membranes that contain a single submicrometer pore or nanopore. This work will be useful for minimizing noise and achieving accurate recordings in nanopore-based experiments.
2007
31. "Designing nanosensors based on charged derivatives of gramicidin A"
Capone R., Blake S., Rincon Restrepo M., Yang J.*, Mayer M.*
J. Am. Chem. Soc., 2007, 129, 9737-9745. Abstract , Full Text (pdf)
  This paper discusses five key design parameters to optimize the performance of chemomodulated ion channel sensors based on derivatives of gramicidin A. Charge-based ion channel sensors offer tremendous potential for ultrasensitive functional detection since a single chemical modification of each individual sensing element can lead to readily detectable changes in channel conductance.
30. "The herpes simplex virus cellular receptor, B5, contains a functional region that induces membrane fusion"
Lopez S.R., Estes D.J., Mayer M., Fuller A.O.*
Submitted, 2007.		  
29. "Estimation of solid phase affinity constants using resistive-pulses from functionalized nanoparticles"
Uram J. D., Mayer M.*
Biosensors and Bioelectronics, 2007, 22, 1556-1560. Abstract , Full Text (pdf)
  This paper describes a method for estimating the solid phase affinity constant of antibodies by using resistive-pulse (Coulter counting) data from spherical nanoparticles that expose antigens.
2006
28. "Monitoring chemical reactions by using ion channel-forming peptides"
Blake S., Mayer T., Mayer M.*, Yang J.*
ChemBioChem, 2006, 7 , 433-435. Abstract , Full Text (pdf)
  This paper presents a method for monitoring chemical reactions on individual molecules by measuring functional changes in ion channel peptides modified with different chemical groups.
27. "Submicrometer pore-based characterization and quantification of antibody-virus interactions"
Uram J. D., Ke K., Hunt A. J., Mayer M.*
Small, 2006, 2, 967-972. Abstract , Full Text (pdf)
  This paper describes the use of a submicrometer pore-based resistive-pulse sensor to i) detect a specific virus or a virus-specific antibody in solution, ii) probe the ability of an antibody to immunoprecipitate the virus, iii) determine the number of antibodies bound to individual virus particles, and iv) monitor the assembly of nanoparticles on templates (here antibodies on viruses) in situ.
26. "Assays for studying annexin binding to artificial lipid bilayers"
Majd S., Estes D. J. (S.M. and D.J.E. contribued equally), Mayer M.*
Calcium Binding Proteins, 2006, 1:1, 26-29. Abstract , Full Text (pdf)
  This paper describes two new techniques for investigating the interactions of annexins with lipid bilayers of well-defined compositions, one approach using hydrogel-stamped supported lipid bilayers, and the other approach using surface-attached giant liposomes in microfluidic chambers.
25. "Triggering and visualizing the aggregation and fusion of lipid membranes in microfluidic chambers"
Estes D. J., Lopez S. R., Fuller A. O., Mayer M.*
Biophysical Journal, 2006, 91, 233-243. Abstract , Full Text (pdf)
  We present a method that makes it possible to trigger, observe, and quantify membrane aggregation and fusion of giant liposomes in microfluidic chambers.
24. "Label-free affinity assays by rapid detection of immune complexes in submicrometer pores"
Uram J. D., Ke K., Hunt A. J., Mayer M.*
Angew. Chem. Int. Ed., 2006, 45, 2281-2285. Abstract , Full Text (pdf)
  We present a method that uses a submicrometer pore to detect and characterize immune complexes consisting of proteins such as staphylococcal enterotoxin B (an agent with bioterrorism potential) and polyclonal antibodies.
2005
23. "Hydrogel-stamping of arrays of supported lipid bilayers with various lipid compositions for screening of drug-membrane and protein-membrane interactions"
Majd S., Mayer M.*
Angew. Chem. Int. Ed., 2005, 44, 6697-6700. Abstract , Full Text (pdf)
  Herein we describe a rapid, reproducible, and straightforward method to form copies of functional membrane arrays with various lipid compositions and the application of these arrays for the screening of drug–membrane and protein–membrane interactions.
  This article was highlighted in Nature Chemical Biology (November 6, 2005) and UM News Service (November 21, 2005).
22. "Giant liposomes in physiological buffer using electroformation in a flow chamber"
Estes D. J., Mayer M.*
Biochim. Biophys. Acta, 2005, 1712, 152-160. Abstract , Full Text (pdf)
  We describe a method to obtain giant liposomes (diameter 10–100 um) in solutions of high ionic strength to perform a membrane-binding assay under physiological conditions.
21. "Electroformation of giant liposomes from spin-coated films of lipids"
Estes D. J., Mayer M.*
Colloids and Surf. B., 2005, 42, 115-123. Abstract , Full Text (pdf)
  This paper describes spin-coating of solutions of lipids and using the resulting thin films for electroformation of giant liposomes.
  1. Michael Mayer's Papers from the Langer Lab, MIT (in collaboration with the Whitesides Lab)
  2. 20. "Direct Patterning of mammalian cells onto porous tissue engineering substrates using agarose stamps"
    Stevens M. M., Mayer M. (S.M.M. and M.M. contribued equally), Anderson D. G., Weibel D. B., Whitesides G. M., Langer R.*
    Biomaterials, 2005, 26(36), 7636-7641. Abstract , Full Text (pdf)
  3. Michael Mayer's Papers from the Whitesides Lab, Harvard University
  4. 19. "Sorting and directing motile escherichia coli"
    DiLuzio W. R., Turner L., Hulme E., Mayer M., Berg H. C., Whitesides G. M.
    in preparation (advanced draft), 2005.
  5. 18. "Quantifying protein-ligand interactions using ion channel-forming peptides"
    Mayer M.*, Semetey V., Gitlin I., Yang J., Whitesides G.M.*
    J. Am. Chem. Soc., 2008, 130, 1453-1465. Abstract, Full Text (pdf)
  6. 17. "Microoxen: microorganisms to move microscale loads"
    Weibel D. B., Garstecki P., Ryan D., DiLuzio W., Mayer M., Seto J. E., Whitesides G. M.*
    Proc. Nat. Acad. Sci. USA, 2005, 102, 11963-11967. Abstract, Full Text (pdf)
  7. 16. "Escherichia coli drive on the right"
    DiLuzio W. R., Turner L., Mayer M., Garstecki P., Weibel D. B., Berg H. C., Whitesides G. M.*
    Nature, 2005, 435, 1271-1274. Abstract, Full Text (pdf), Supplementary Movie (mpeg)
  8. 15. "A bacterial printing press that regenerates its ink: contact printing bacteria using hydrogel stamps"
    Weibel D. B., Lee A., Mayer M., Brady S. F., Bruzewicz D., Yank J., DiLuzio W., Clardy J., Whitesides G. M.*
    Langmuir, 2005, 21(14), 6436-6442. Abstract , Full Text (pdf), Cover Image
  9. 14. "Micropatterned agarose gels for stamping arrays of proteins and gradients of proteins"
    Mayer M., Yang J., Gracias D., Whitesides G. M.*
    Proteomics, 2004, 4, 2366-2376. Abstract , Full Text (pdf)
  10. 13. "Self-Assembled Aggregates of IgGs as Templates for the Growth of Clusters of Gold Nanoparticles"
    Yang J., Mayer M., Kriebel J. K., Garstecki P., Whitesides. G. M.*
    Angew. Chem. Int. Ed., 2004, 43, 1555-1558. Abstract , Full Text (pdf)
  11. 12. "Microfabricated Teflon membranes for low-noise recordings of ion channels in planar lipid bilayers"
    Mayer M.*, Kriebel J. K., Tosteson M. T., Whitesides G. M.*
    Biophys. J., 2003, 85, 2684-2695. Abstract , Full Text (pdf)
  12. 11. "Significance of charge regulation in the analysis of protein charge ladders"
    Gitlin I., Mayer M., Whitesides G. M.*
    J. Phys. Chem. B., 2003, 107, 1466-1472. Abstract , Full Text (pdf)
  13. 10. "Membraneless vanadium redox fuel cell using laminar flow"
    Ferrigno R., Stroock A. D., Clark T. D., Mayer M., Whitesides G. M.*
    J. Am. Chem. Soc., 2002, 124, 12930-12931. Abstract , Full Text (pdf)
  14. Michael Mayer's Papers from Swiss Federal Institute of Technology, Lausanne, Switzerland
  15. 9. "Highly electrically insulating tethered lipid bilayers for probing the function of ion channel proteins"
    Terrettaz S., Mayer M., Vogel H.
    Langmuir, 2003, 19, 5567-5569. Abstract , Full Text (pdf)
  16. 8. "Reversible immobilization of peptides: surface modification and in situ detection by ATR-FTIR spectroscopy"
    Rigler P. H. A., Ulrich W.-P., Hoffmann P, Mayer M., Vogel H.*
    ChemPhysChem, 2003, 4, 268-275. Abstract , Full Text (pdf)
  17. 7. "Monitoring the formation of densely packed recombinant receptors during clustering in the plasma membranes of live biological cells"
    Pick H. M., Preuss A. K., Mayer M., Wohland T., Hovius R., Vogel H.*
    Biochemistry, 2003, 42, 877-884. Abstract , Full Text (pdf)
  18. 6. "Functional analysis of ion channels: Planar patch clamp and impedance spectroscopy of tethered lipid membranes"
    Mayer M., Terrettaz S., Giovangrandi L., Stora T., Vogel H.*
    In: Biosensors - A practical Approach, 2nd Ed., Oxford University Press, Oxford, UK, 2003. Link , Full Text (pdf)
  19. 5. "A chip-based biosensor for the functional analysis of single ion channels"
    Schmidt C., Mayer M., Vogel H.*
    Angew. Chem. Int. Ed., 2000, 39, 3137-3140. Abstract , Full Text (pdf)
  20. 4. "Immunoaffinity screening with capillary electrochromatography"
    Mayer M., Muscate-Magnussen A., Vogel H., Ehrat M., Bruin G. J. M.*
    Electrophoresis, 2002, 23, 1255-1262. Abstract , Full Text (pdf)
  21. Michael Mayer's Papers from Novartis Pharma AG, Basel, Switzerland
  22. 3. "Fritless capillary electrochromatography"
    Mayer M., Rapp E., Marck C., Bruin G. J. M.*
    Electrophoresis, 1999, 20, 43-49. Abstract , Full Text (pdf)
  23. Michael Mayer's Papers from the University of Washington, Seattle
  24. 2. "Flow injection based renewable electrochemical sensor system"
    Mayer M., Ruzicka J.*
    Anal. Chem., 1996, 68, 3808-3814. Abstract , Full Text (pdf)
  25. Michael Mayer's Papers from Federal Institute for Biotechnology, Braunschweig, Germany
  26. 1. "Automated determination of lactulose in milk using an enzyme reactor and flow analysis with integrated dialysis"
    Mayer M., Genrich M., Kuennecke W., Bilitewski U.*
    Anal. Chim. Acta, 1996, 324, 37-45. Abstract , Full Text (pdf)
Property of the Biomembrane lab, University of Michigan, 2005
Maintained and created by The Webmaster

This material is based upon work supported by the National Science Foundation under Grant No. 0449088.

Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.